Is Thyroid Eye Disease more often associated with hyperthyroidism or hypothyroidism?

Is Thyroid Eye Disease more often associated with hyperthyroidism or hypothyroidism?

• A. Hyperthyroidism
• B. Hypothyroidism
• C. Euthyroid
• D. Thyroid cancer

Answer: (A)

Thyroid Eye Disease is most strongly linked to autoimmune hyperthyroidism, specifically Graves’ disease. In Graves’, antibodies stimulate TSH receptors not only in the thyroid but also in orbital tissues, triggering inflammation, fat and extraocular muscle expansion, and edema. This orbital autoimmune process leads to proptosis, lid retraction, and motility issues. While TED can occur with hypothyroidism or even in euthyroid states, the typical and most frequent association is with hyperthyroidism from Graves’ disease. Thyroid cancer is not a common association.

Thyroid Eye Disease is most strongly linked to autoimmune hyperthyroidism, specifically Graves’ disease. In Graves’, antibodies stimulate TSH receptors not only in the thyroid but also in orbital tissues, triggering inflammation, fat and extraocular muscle expansion, and edema. This orbital autoimmune process leads to proptosis, lid retraction, and motility issues. While TED can occur with hypothyroidism or even in euthyroid states, the typical and most frequent association is with hyperthyroidism from Graves’ disease. Thyroid cancer is not a common association.