Which statement about CIN is true?

Which statement about CIN is true?

• A. It is a benign, non-progressive lesion
• B. It is a pigmented lesion arising from nevus
• C. It is caused by bacterial infection
• D. It is a conjunctival neoplasia that can progress to squamous cell carcinoma

Answer: (D)

Conjunctival intraepithelial neoplasia is a dysplastic change confined to the surface epithelium of the conjunctiva, and it has the potential to progress to invasive squamous cell carcinoma. This is why it’s described as a conjunctival neoplasia that can become squamous cell carcinoma. It’s not simply benign or non-progressive, and it’s not typically a pigmented lesion arising from a nevus, nor is it caused by bacterial infection. In practice, CIN is treated to remove the abnormal epithelium and prevent invasion, often with surgical excision and adjuvant therapy as needed.